For all components of the “portfolio” assignment series:
•    hand drawing is required
•    any explanations longer than a sentence must be typed
•    labeling and short explanations may be neatly handwritten
•    everything must be neat and legible
•    drawings should be sufficiently large and spread out that all components are easily distinguished and sufficient detail is included
•    no cut and paste from hard copy sources or electronic sources

IV.  Thermodynamics Descriptions and Calculations                                     due January 25, 2011
    Define in mathematical terms or equations and in English
•    the First Law of Thermodynamics
•    the Second Law of Thermodynamics
•    entropy
•    enthalpy
•    the relationship between enthalpy and entropy

V.  Gibbs Free Energy Calculations                                                                due January 25, 2011
•    Define in mathematical terms or equations and in English
    •    Gibbs free energy
    •    the relationship between {any convenient term for energy} and G, specifcally: for this, a series of equations is required (~ a proof)
    •    ΔG
    •    ΔGo: for this, a series of equations is required (~ a proof)
    •    ΔGo’: for this, a series of equations is required (~ a proof)
•    Explain why we use G rather than some other term for energy to describe biological systems

VI.  Rates of Reaction and Equilibrium Constants                                             due January 27, 2011
•    Define in mathematical terms or equations and in English
    •    Keq
    •    K’eq
•    What is k?  Give an example of how this term is used
•    Define K in terms of k (or multiple k terms) using mathematical terms, and in English
•    Define or describe the rate of a reaction, V, in terms of K and k terms

VII.  Michaelis-Menton Model                                ** new due date!              due February 1, 2011   February 15    ***

A.  Simple conditions
•    Show a representative reaction equation for a substrate binding an enzyme followed by product formation and enzyme release
•    In that reaction equation, show rates of all forward and back reactions
•    Define V
•    Explain Vo = k2 [ES] : show mathematical derivation and explain, in English, Vo and k2
•    Define KM, the Michaelis-Menton constant: show mathematical derivation
•    Explain Vmax = k2 [E]T : show mathematical derivation and explain, in English, Vmax
•    Describe ΔV: why would V change (that is, how can there be a “Δ”, a change in V)?

B.  Altered or complex conditions
•    What might cause a change in [that is, what sort of change in the components of the system might have this effect?] - explain, and sketch both kinetic and Lineweaver-Burk graphs of these situations.
    •    Vmax and KM ?
    •    Vmax but not KM ?
    •    KM but not Vmax ?